| Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc |
| Journal website http://www.neurores.org |
Case Report
Volume 5, Number 1-2, April 2015, pages 186-191
Human Embryonic Stem Cells in the Treatment of Patients With Duchenne Muscular Dystrophy: A Case Series
Table
| Cases | Age (years) | Admitted on | Chief complaints | DNA analysis | CPK (before treatment) (IU/L) | CPK (after treatment) (IU/L) | Immunohistochemistry |
|---|---|---|---|---|---|---|---|
| 1 | 16 | April 26, 2010 | Loss of balance, scoliosis, inability to stand or walk, sit straight and turn on sides and wheelchair bound since 2005 | Partial dystrophin gene deletion spanning exons 5 to 7 | 3,307 | 976 | - |
| 2 | 13 | April 12, 2006 | Muscle weakness in all muscle groups (proximal > distal), stiffness in wrist and fingers, tightness of all joints, impaired fine hand functions, difficulty in holding pen and poor hand grip, unable to stand or walk, poor sitting balance an wheelchair bound since 2 years | - | 1,775 | 572 | Negative for dystrophin 1 and 3 while reduced and patchy for dystrophin 1 |
| 3 | 6 | June 19, 2006 | Muscle weakness (proximal > distal), decreased stamina, difficulty in standing and inability to walk properly | A deletion in the dystrophin gene of exon 44 | 6,922 | 412 | Negative for Dys 2, but reduced and patchy for Dys 1 |
| 4 | 14 | June 11, 2004 | Muscle weakness, flexion deformity in B/L elbows and knees, inability to turn on sides and lift his arms or legs without support | - | 2343 | 1220 | - |
| 5 | 21 | July 2008 | Muscle weakness (proximal > distal), inability to stand or walk even with support, difficulty in turning himself, impaired hand functions and wheelchair bound | - | 1,198 | 640 | Dys l, 2, 3, alpha, beta, gamma, delta sarcoglycans showed normal staining pattern |