J Neurol Res

Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc

Journal website http://www.neurores.org

Original Article

Volume 5, Number 6, December 2015, pages 283-290

Cognitive Dysfunction in Patients With Rapid Eye Movement Dependent and Other Types of Obstructive Sleep Apnea Syndrome

**Table 1.** Comparison of Sociodemographic Characteristics of the Groups
	ROSAS, mean ± SD (n = 20)	COSAS, mean ± SD (n = 50)	t/χ²	P
SD: standard deviation. *P < 0.05 values found statistically significant.
Gender
Woman	11	52.4	10	47.6	8.33	0.00*
Man	9	18.4	40	81.6
Marital status
Single	1	5	2	4	1.98	0.57
Married	14	70	42	84
Widowed	2	10	2	4
Divorced	3	15	4	8
Education qualification
Elementary education	9	45	23	46	0.33	0.84
High school	3	15	10	20
College	8	40	17	34
	Mean ± SD	Mean ± SD	t	P
Age	53.45 ± 11.61	47.28 ± 11.33	2.04	0.05*
Height	165.7 ± 9.56	170.66 ± 7.64	-2.27	0.02*
Weight	84.75 ± 13.60	91.14 ± 17.82	-1.44	0.15
Body mass index	31.02 ± 5.64	31.27 ± 4.96	-0.18	0.85
Neck circumference	38.92 ± 3.85	41.45 ± 4.04	-2.39	0.02*
Waist circumference	103.85 ± 11.07	109.4 ± 14.65	-1.52	0.13

Table 1. Comparison of Sociodemographic Characteristics of the Groups

ROSAS, mean ± SD (n = 20)

COSAS, mean ± SD (n = 50)

t/χ²

SD: standard deviation. *P < 0.05 values found statistically significant.

Gender

Woman

52.4

47.6

8.33

0.00*

Man

18.4

81.6

Marital status

Single

1.98

0.57

Married

Widowed

Divorced

Education qualification

Elementary education

0.33

0.84

High school

College

Mean ± SD

Age

53.45 ± 11.61

47.28 ± 11.33

2.04

0.05*

Height

165.7 ± 9.56

170.66 ± 7.64

-2.27

0.02*

Weight

84.75 ± 13.60

91.14 ± 17.82

-1.44

0.15

Body mass index

31.02 ± 5.64

31.27 ± 4.96

-0.18

0.85

Neck circumference

38.92 ± 3.85

41.45 ± 4.04

-2.39

0.02*

Waist circumference

103.85 ± 11.07

109.4 ± 14.65

-1.52

0.13

**Table 2.** Comparison of Clinical Characteristics of the Groups
Variables	ROSAS (n = 20)	COSAS (n = 50)	t	P
*P < 0.05 values found statistically significant.
Epworth	7.85 ± 5.97	8.82 ± 4.68	-0.72	0.47
Total time analyzed	413.24 ± 2287	422.49 ± 22.98	-1.52	0.13
Total sleep time	357.63 ± 65.56	373.14 ± 47.59	-1.10	0.27
Sleep latency	11.11 ± 12.33	8.5 ± 7.69	1.07	0.28
REM latency	128.5 ± 93.97	153.47 ± 91.62	-1.01	0.31
Arousal index	17.33 ± 12.47	61.35 ± 38.76	-4.95	0.00*
N1%	3.51 ± 2.11	4.82 ± 3.01	-1.78	0.07
N2%	59.87 ± 16.16	82.81 ± 74.08	-1.36	0.17
N3%	23.36 ± 15.82	16.25 ± 18.67	1.49	0.13
REM%	13.17 ± 4.57	8.25 ± 6.28	3.17	0.00*
AHI	11.33 ± 3.82	37.23 ± 27.04	-4.24	0.00*
Mean apnea duration	20.46 ± 4.29	24.13 ± 5.72	-2.58	0.01*
Lowest oxygen Saturation	81.85 ± 7.48	77.75 ± 10.34	1.60	0.11
Oxygen desaturation index	9.63 ± 4.95	35.73 ± 26.46	-4.36	0.00*
Periodic limb movements index	6.01 ± 11.35	24.10 ± 26.59	-2.92	0.00*
Longest apnea duration	48.74 ± 18.2	61.62 ± 19.93	0.01	0.99

Table 2. Comparison of Clinical Characteristics of the Groups

Variables

ROSAS (n = 20)

COSAS (n = 50)

*P < 0.05 values found statistically significant.

Epworth

7.85 ± 5.97

8.82 ± 4.68

-0.72

0.47

Total time analyzed

413.24 ± 2287

422.49 ± 22.98

-1.52

0.13

Total sleep time

357.63 ± 65.56

373.14 ± 47.59

-1.10

0.27

Sleep latency

11.11 ± 12.33

8.5 ± 7.69

1.07

0.28

REM latency

128.5 ± 93.97

153.47 ± 91.62

-1.01

0.31

Arousal index

17.33 ± 12.47

61.35 ± 38.76

-4.95

0.00*

N1%

3.51 ± 2.11

4.82 ± 3.01

-1.78

0.07

N2%

59.87 ± 16.16

82.81 ± 74.08

-1.36

0.17

N3%

23.36 ± 15.82

16.25 ± 18.67

1.49

0.13

REM%

13.17 ± 4.57

8.25 ± 6.28

3.17

0.00*

AHI

11.33 ± 3.82

37.23 ± 27.04

-4.24

0.00*

Mean apnea duration

20.46 ± 4.29

24.13 ± 5.72

-2.58

0.01*

Lowest oxygen Saturation

81.85 ± 7.48

77.75 ± 10.34

1.60

0.11

Oxygen desaturation index

9.63 ± 4.95

35.73 ± 26.46

-4.36

0.00*

Periodic limb movements index

6.01 ± 11.35

24.10 ± 26.59

-2.92

0.00*

Longest apnea duration

48.74 ± 18.2

61.62 ± 19.93

0.01

0.99

**Table 3.** Comparison of Cognitive Functions of the Groups
Variables	ROSAS (n = 20)	COSAS (n = 50)	Z	P
TWTS: Three Words Three Shapes. *P < 0.05 values found statistically significant.
Stroop subtask 1 speed	37.05	34.88	-0.40	0.68
Stroop subtask 3 speed	35.05	35.68	-0.11	0.90
Stroop subtask 5 speed	35.3	35.88	-0.05	0.95
Interference	35.7	35.42	-0.05	0.95
Serial digit learning test	33.45	36.32	-0.53	0.59
Trail making test speed	35.8	35.38	-0.07	0.93
Trail making test error	39.85	33.76	-1.21	0.22
TWTS copy shape	35.08	35.67	-0.18	0.85
TWTS copy word	35.5	35.5	0.00	1.00
TWTS incidental recall shape	36.6	35.06	-0.30	0.76
TWTS incidental recall word	34.38	35.95	-0.31	0.75
TWTS delayed recall shape	35.3	35.58	-0.06	0.95
TWTS delayed recall word	32.58	36.67	-0.81	0.41
TWTS recognition shape	36	35.3	0.63	0.52
TWTS recognition word	32.3	36.78	-1.31	0.18

Table 3. Comparison of Cognitive Functions of the Groups

Variables

ROSAS (n = 20)

COSAS (n = 50)

TWTS: Three Words Three Shapes. *P < 0.05 values found statistically significant.

Stroop subtask 1 speed

37.05

34.88

-0.40

0.68

Stroop subtask 3 speed

35.05

35.68

-0.11

0.90

Stroop subtask 5 speed

35.3

35.88

-0.05

0.95

Interference

35.7

35.42

-0.05

0.95

Serial digit learning test

33.45

36.32

-0.53

0.59

Trail making test speed

35.8

35.38

-0.07

0.93

Trail making test error

39.85

33.76

-1.21

0.22

TWTS copy shape

35.08

35.67

-0.18

0.85

TWTS copy word

35.5

0.00

1.00

TWTS incidental recall shape

36.6

35.06

-0.30

0.76

TWTS incidental recall word

34.38

35.95

-0.31

0.75

TWTS delayed recall shape

35.3

35.58

-0.06

0.95

TWTS delayed recall word

32.58

36.67

-0.81

0.41

TWTS recognition shape

35.3

0.63

0.52

TWTS recognition word

32.3

36.78

-1.31

0.18