Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc
Journal website http://www.neurores.org

Original Article

Volume 3, Number 1, February 2013, pages 34-39

Treatment Effect of Donepezil is Greater in Moderate Stage Than in Mild Stage of Alzheimer’s Disease

Tables

Table 1. Baseline Characteristics of the Patients With Alzheimer’s Disease, Mean ± S.D. or (%)
 
VariablesSeverity of Alzheimer’s diseaseP-value
Very mild (CDR 0.5)Mild (CDR 1)Moderate (CDR 2)
Number18815331
Age, years72.02 ± 8.1572.54 ± 8.0477.06 ± 6.600.007
Male gender, %37.026.319.40.03d3
Education, years8.45 ± 5.546.80 ± 5.145.81 ± 4.830.003
Baseline K-MMSE score21.95 ± 3.6317.65 ± 4.5513.61 ± 3.74< 0.001
Baseline CDR-SOB3.07 ± 0.885.92 ± 1.2510.63 ± 1.62< 0.001
Baseline IADL11.97 ± 5.5621.14 ± 8.4830.16 ± 9.84< 0.001
Baseline basic ADL19.88 ± 0.5419.10 ± 2.2717.81 ± 3.14< 0.001
Average period of follow-up, years1.02 ± 0.081.01 ± 0.081.02 ± 0.100.644

 

Table 2. Mean Difference Between the End of One-Year Follow-Up and Baseline With Results of Paired Comparisons Between Severity Groups of Alzheimer’s Disease, Mean ± S.D.
 
Difference between baseline and the end of one-yearSeverity of Alzheimer’s diseaseGroup difference in multiple comparisonStatistical difference by ANCOVA
CDR 0.5CDR 1CDR 2FP-value
Δ = score at the end of one-year follow up - score at baseline. K-MMSE: Korean versions of the mini-mental state examination; CDR-SOB: clinical dementia rating-sum of box; IADL: Instrumental activity of daily living; ADL: Activity of daily living; S.D.: standard deviation.
Δ Mean K-MMSE score-1.37 ± 3.07-1.27 ± 3.20-0.42 ± 3.40n.s.1.030.361
Δ Mean CDR-SOB score-1.36 ± 1.82-1.29 ± 2.31-0.43 ± 3.33CDR 0.5, CDR 1 > CDR 22.770.041
Δ Mean IADL score-5.05 ± 8.10-3.31 ± 9.15-3.29 ± 11.02n.s.1.440.24
Δ Mean basic ADL score-0.40 ± 1.56-0.60 ± 2.60-1.70 ± 3.55CDR 0.5, CDR 1 < CDR 22.940.013