| Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc |
| Journal website http://www.neurores.org |
Original Article
Volume 7, Number 6, December 2017, pages 103-107
Calcitonin Gene-Related Peptide as a Biomarker in Migraine
Tables
| Chronic migraine (n = 20) | Episodic migraine (n = 20) | Tension type and cluster headache (n = 20) | Control (n = 20) | F | P | |
|---|---|---|---|---|---|---|
| F: F value for ANOVA. Sig. between groups was done using post hoc test. PControl: P value for comparing between control and each group. P1: P value for comparing between chronic migraine and episodic migraine. P2: P value for comparing between chronic migraine and tension type and cluster headache. P3: P value for comparing between episodic and tension type and cluster headache. *Statistically significant at P ≤ 0.05. F(3,76) = 2.725. | ||||||
| CGRP | ||||||
| Min. - Max. | 131.8 - 194.6 | 69.6 - 121.9 | 62.8 - 110.8 | 51.7 - 83.65 | 155.09* | < 0.001* |
| Mean ± SD | 165.0 ± 17.9 | 94.1 ± 17.83 | 87.2 ± 13.8 | 70.5 ± 8.36 | ||
| Median | 167.38 | 97.0 | 86.95 | 70.63 | ||
| PControl | < 0.001* | < 0.001* | 0.004* | |||
| Sig. between groups | P1 < 0.001*, P2 < 0.001*, P3 = 0.471 | |||||
| CGRP | Aura | t | P | |
|---|---|---|---|---|
| No | Yes | |||
| t, P: t and P values for Student’s t-test for comparing between the two groups. *Statistically significant at P ≤ 0.05. T(18) = 2.101. | ||||
| Chronic migraine | n = 17 | n = 3 | ||
| Min. - Max. | 131.80 - 186.0 | 185.45 - 194.60 | 3.493* | 0.003* |
| Mean ± SD | 160.30 ± 14.93 | 191.32 ± 5.09 | ||
| Median | 157.80 | 193.90 | ||
| Episodic migraine | n = 16 | n = 4 | ||
| Min. - Max. | 69.60 - 121.90 | 100.70 - 116.30 | 3.407* | 0.005* |
| Mean ± SD | 90.16 ± 17.56 | 109.88 ± 7.54 | ||
| Median | 93.05 | 111.25 | ||
| Group parameter | CGRP | |||
|---|---|---|---|---|
| Chronic migraine | Episodic migraine | Tension type and cluster headache | Control | |
| r: Pearson coefficient. | ||||
| Age (years) | ||||
| r | -0.252 | -0.199 | -0.008 | -0.123 |
| P | 0.285 | 0.400 | 0.973 | 0.607 |
| Severity | ||||
| r | 0.085 | 0.189 | 0.354 | - |
| P | 0.721 | 0.426 | 0.125 | - |
| Frequency/month | ||||
| r | -0.092 | 0.088 | 0.089 | - |
| P | 0.700 | 0.712 | 0.710 | - |
| Duration/attack (h) | ||||
| r | 0.129 | 0.077 | 0.235 | - |
| P | 0.588 | 0.748 | 0.319 | - |