J Neurol Res

Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc

Journal website http://www.neurores.org

Original Article

Volume 10, Number 2, April 2020, pages 38-43

May Neutrophil to Lymphocyte Ratio Serve a Role in the Prediction of Clinical Features of Migraine?

**Table 1.** The Demographic and Clinical Features of the Overall Patient Group
	Overall patient group (n = 52)
NLR: neutrophil to lymphocyte ratio; SD: standard deviation; F/M: female/male; FACIT fatigue scale: the Functional Assessment of Chronic Illness Therapy fatigue scale.
Age (mean ± SD)	37.3 ± 11.8
Gender (F/M)	49/3
Episodic/chronic	36/16
BMI (mean ± SD)	27.5 ± 5.4
Tinnitus	26/52
Fibromyalgia	26/52
Chronic fatigue syndrome	47/52
The presence of cognitive symptoms	40/52
FACIT fatigue scale (mean ± SD)	30.5 ± 10.1
Headache impact test (mean ± SD)	23.0 ± 3.7
Headache frequency per month (median (range))	8 (23)
NLR (median (range))	2.0 (7.8)

Table 1. The Demographic and Clinical Features of the Overall Patient Group

Overall patient group (n = 52)

NLR: neutrophil to lymphocyte ratio; SD: standard deviation; F/M: female/male; FACIT fatigue scale: the Functional Assessment of Chronic Illness Therapy fatigue scale.

Age (mean ± SD)

37.3 ± 11.8

Gender (F/M)

49/3

Episodic/chronic

36/16

BMI (mean ± SD)

27.5 ± 5.4

Tinnitus

26/52

Fibromyalgia

26/52

Chronic fatigue syndrome

47/52

The presence of cognitive symptoms

40/52

FACIT fatigue scale (mean ± SD)

30.5 ± 10.1

Headache impact test (mean ± SD)

23.0 ± 3.7

Headache frequency per month (median (range))

8 (23)

NLR (median (range))

2.0 (7.8)

**Table 2.** The Comparisons of Demographic and Clinical Features and the Results of Questionnaires Between Episodic Migraineurs and Chronic Migraineurs
	Episodic migraine (n = 36)	Chronic migraine (n = 16)	P value
*P < 0.05. NLR: neutrophil to lymphocyte ratio; SD: standard deviation; F/M: female/male; BMI: body mass index; FACIT fatigue scale: the Functional Assessment of Chronic Illness Therapy fatigue scale.
Age (mean ± SD)	37.3 ± 11.9	37.3 ± 11.7	0.991
Gender (F/M)	34/2	15/1	0.921
BMI (mean ± SD)	27.2 ± 5.4	28.1 ± 5.7	0.595
The presence of fibromyalgia	17/36	9/16	0.548
The presence of chronic fatigue syndrome	32/36	15/16	0.583
The presence of cognitive symptoms	29/36	11/16	0.351
FACIT fatigue scale (mean ± SD)	28.7 ± 9.2	34.5 ± 11.0	0.056
Headache impact test (median (range))	22(15)	25.5 (13)	0.024*
Headache frequency per month (median (range))	5 (10)	18 (10)	0.000*
NLR (median (range))	2.1 (2.7)	1.7 (7.8)	0.230

Table 2. The Comparisons of Demographic and Clinical Features and the Results of Questionnaires Between Episodic Migraineurs and Chronic Migraineurs

Episodic migraine (n = 36)

Chronic migraine (n = 16)

P value

*P < 0.05. NLR: neutrophil to lymphocyte ratio; SD: standard deviation; F/M: female/male; BMI: body mass index; FACIT fatigue scale: the Functional Assessment of Chronic Illness Therapy fatigue scale.

Age (mean ± SD)

37.3 ± 11.9

37.3 ± 11.7

0.991

Gender (F/M)

34/2

15/1

0.921

BMI (mean ± SD)

27.2 ± 5.4

28.1 ± 5.7

0.595

The presence of fibromyalgia

17/36

9/16

0.548

The presence of chronic fatigue syndrome

32/36

15/16

0.583

The presence of cognitive symptoms

29/36

11/16

0.351

FACIT fatigue scale (mean ± SD)

28.7 ± 9.2

34.5 ± 11.0

0.056

Headache impact test (median (range))

22(15)

25.5 (13)

0.024*

Headache frequency per month (median (range))

5 (10)

18 (10)

0.000*

NLR (median (range))

2.1 (2.7)

1.7 (7.8)

0.230

**Table 3.** The Possible Utility of NLR in Discriminating the Migraineurs According to the Presence of Fibromyalgia, Chronic Fatigue Syndrome, Tinnitus and Cognitive Symptoms, Respectively
	The results of the comparisons of NLR between the patient groups (P values)
NLR: neutrophil to lymphocyte ratio; FM: fibromyalgia: CFS: chronic fatigue syndrome.
Episodic and chronic migraine	0.230
FM (+) and FM (-) groups	0.647
CFS (+) and CFS (-) groups	0.331
Tinnitus (+) and tinnitus (-) groups	0.721
Cognitive symptoms (+) and (-) groups	0.143

Table 3. The Possible Utility of NLR in Discriminating the Migraineurs According to the Presence of Fibromyalgia, Chronic Fatigue Syndrome, Tinnitus and Cognitive Symptoms, Respectively

The results of the comparisons of NLR between the patient groups (P values)

NLR: neutrophil to lymphocyte ratio; FM: fibromyalgia: CFS: chronic fatigue syndrome.

Episodic and chronic migraine

0.230

FM (+) and FM (-) groups

0.647

CFS (+) and CFS (-) groups

0.331

Tinnitus (+) and tinnitus (-) groups

0.721

Cognitive symptoms (+) and (-) groups

0.143

**Table 4.** The Results of the Correlation Analyses
The correlation analyses	The correlation coefficient (r)	P value
*P < 0.05. NLR: neutrophil to lymphocyte ratio; FACIT fatigue scale: the Functional Assessment of Chronic Illness Therapy fatigue scale; HIT-6: headache impact test; BMI: body mass index.
NLR/FACIT fatigue scale	-0.226	0.108
NLR/HIT-6	-0.090	0.526
FACIT fatigue scale/HIT-6	0.322	0.020*
FACIT fatigue scale/headache frequency per month	0.497	0.000*
BMI/FACIT fatigue scale score	-0.007	0.962
BMI/headache frequency per month	-0.072	0.614

Table 4. The Results of the Correlation Analyses

The correlation analyses

The correlation coefficient (r)

P value

*P < 0.05. NLR: neutrophil to lymphocyte ratio; FACIT fatigue scale: the Functional Assessment of Chronic Illness Therapy fatigue scale; HIT-6: headache impact test; BMI: body mass index.

NLR/FACIT fatigue scale

-0.226

0.108

NLR/HIT-6

-0.090

0.526

FACIT fatigue scale/HIT-6

0.322

0.020*

FACIT fatigue scale/headache frequency per month

0.497

0.000*

BMI/FACIT fatigue scale score

-0.007

0.962

BMI/headache frequency per month

-0.072

0.614