J Neurol Res

Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc

Journal website http://www.neurores.org

Original Article

Volume 1, Number 5, December 2011, pages 193-200

Serum Uric Acid Levels in Acute Ischemic Stroke: A Study of 100 Patients

**Table 1.** Comparison of Conventional Risk Factors for Ischemic Stroke (Confounding Variables) Between Cases and Controls (Univariate Analysis)
Variable	Case	Control	Total	P value
Age (years)	60.05 ± 9.98	60.32 ± 10.11	60.18 ± 10.02	0.850
Hypertension	Yes	51	11	62	χ² = 37.40 OR = 8.42 95% C.I. = 4.02 - 17.63 P = 0.00
	No	49	89	138
Diabetes mellitus	Yes	23	11	34	χ² = 5.103 OR = 2.41 95% C.I. = 1.10-5.27 P = 0.023
	No	77	89	166
Metabolic syndrome	Yes	40	8	48	χ² = 28.07 OR = 7.66 95% C.I. = 3.35 - 17.50 P = 0.000
	No	60	92	152
Smoking	Yes	20	8	28	χ² = 5.98 OR = 2.87 95% C.I. = 1.20 - 6.88 P = 0.014
	No	80	92	172
Obesity	Yes	44	6	50	χ² = 38.57 OR = 12.31 95% C.I. = 4.93 - 30.73 P = 0.000
	No	56	94	150
BMI	25.13 ± 3.13	22.93 ± 2.88		t = 5.178 P = 0.00

Table 1. Comparison of Conventional Risk Factors for Ischemic Stroke (Confounding Variables) Between Cases and Controls (Univariate Analysis)

Variable

Case

Control

Total

P value

Age (years)

60.05 ± 9.98

60.32 ± 10.11

60.18 ± 10.02

0.850

Hypertension

Yes

χ² = 37.40
OR = 8.42 95%
C.I. = 4.02 - 17.63
P = 0.00

138

Diabetes mellitus

Yes

χ² = 5.103
OR = 2.41 95%
C.I. = 1.10-5.27
P = 0.023

166

Metabolic syndrome

Yes

χ² = 28.07
OR = 7.66 95%
C.I. = 3.35 - 17.50
P = 0.000

152

Smoking

Yes

χ² = 5.98
OR = 2.87 95%
C.I. = 1.20 - 6.88
P = 0.014

172

Obesity

Yes

χ² = 38.57
OR = 12.31 95%
C.I. = 4.93 - 30.73
P = 0.000

150

BMI

25.13 ± 3.13

22.93 ± 2.88

t = 5.178
P = 0.00

**Table 2.** Comparison of Serum Uric Acid Levels in Cases and Controls
	Cases	Controls	P value
Mean SUA	6.48 ± 1.92	5.09 ± 1.07	0.00
Range	2.1 - 12	2.1 - 8
Median	6.55	4.9

Table 2. Comparison of Serum Uric Acid Levels in Cases and Controls

Cases

Controls

P value

Mean SUA

6.48 ± 1.92

5.09 ± 1.07

0.00

Range

2.1 - 12

2.1 - 8

Median

6.55

4.9

**Table 3.** Multiple Logistic Regression Analysis Showing Association of Various Risk Factors With Ischemic Stroke
Risk factor	Odds ratio	Z value	95% Confidence interval	P value
Hypertension	0.152	-3.936	-2.824	-0.947	0.000
Diabetes Mellitus	0.960	-0.062	-1.339	1.257	0.951
Metabolic syndrome	0.655	-0.628	-1.741	0.896	0.530
Smoking	0.405	-1.966	-1.805	-0.003	0.049
SUA	1.487	3.625	0.182	0.611	0.000
Obesity	0.116	-3.636	-3.321	-0.995	0.000

Table 3. Multiple Logistic Regression Analysis Showing Association of Various Risk Factors With Ischemic Stroke

Risk factor

Odds ratio

Z value

95% Confidence interval

P value

Hypertension

0.152

-3.936

-2.824

-0.947

0.000

Diabetes Mellitus

0.960

-0.062

-1.339

1.257

0.951

Metabolic syndrome

0.655

-0.628

-1.741

0.896

0.530

Smoking

0.405

-1.966

-1.805

-0.003

0.049

SUA

1.487

3.625

0.182

0.611

0.000

Obesity

0.116

-3.636

-3.321

-0.995

0.000

**Table 4.** Relationship of SUA With Age
Age	No. of patients (n = 200)	Mean SUA
< 50	26	5.43 ± 1.98
50 - 59	65	5.87 ± 1.69
60 - 69	69	5.77 ± 1.69
≥ 70	40	5.88 ± 1.56

Table 4. Relationship of SUA With Age

Age

No. of patients (n = 200)

Mean SUA

< 50

5.43 ± 1.98

50 - 59

5.87 ± 1.69

60 - 69

5.77 ± 1.69

≥ 70

5.88 ± 1.56

**Table 5.** Relationship of SUA With HDL Cholesterol
SUA (mg/dl)	Mean HDL cholesterol (mg/dl)
< 5	49.19 ± 8.71	r = -0.334 P = 0.001
5 - 5.9	46.74 ± 7.67
6 - 6.9	44.14 ± 9.99
≥ 7	41.11 ± 10.17

Table 5. Relationship of SUA With HDL Cholesterol

SUA (mg/dl)

Mean HDL cholesterol (mg/dl)

< 5

49.19 ± 8.71

r = -0.334
P = 0.001

5 - 5.9

46.74 ± 7.67

6 - 6.9

44.14 ± 9.99

≥ 7

41.11 ± 10.17

**Table 6.** Relationship of SUA With Serum Triglyceride Level
SUA (mg/dl)	Mean triglyceride level (mg/dl)
5	123.56 ± 33.91	r = 0.294 P = 0.001
5 - 5.9	126.27 ± 43.11
6 - 6.9	147.97 ± 42.78
≥ 7	156.90 ± 45.40

Table 6. Relationship of SUA With Serum Triglyceride Level

SUA (mg/dl)

Mean triglyceride level (mg/dl)

123.56 ± 33.91

r = 0.294
P = 0.001

5 - 5.9

126.27 ± 43.11

6 - 6.9

147.97 ± 42.78

≥ 7

156.90 ± 45.40

**Table 7.** Relationship of SUA With National Institute of Health Stroke Scale (NIHSS) Score
		NIHSSS on admission	NIHSSS on discharge
Serum uric acid	Number of patients	100	87
	r value	0.407	0.398
	P value	0.000	0.000

Table 7. Relationship of SUA With National Institute of Health Stroke Scale (NIHSS) Score

NIHSSS on admission

NIHSSS on discharge

Serum uric acid

Number of patients

100

r value

0.407

0.398

P value

0.000