J Neurol Res

Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc

Journal website http://www.neurores.org

Original Article

Volume 2, Number 1, February 2012, pages 10-15

Cardiovascular Disease Risk Profile in Japanese Midlife Migraineurs

**Table 1.** Clinical Background of Migraineurs
	Total (n =596)	Women (n = 409)	Men (n = 187)
MA: migraine with aura; MO: migraine without aura; HIT-6: headache impact test-6. *P < 0.01 between women and men.
Mean age (SD) years	44.6 (9.4)	44.3 (9.4)	45.2 (9.3)
Mean duration of migraine (SD) years	16.7 (11.4)	18.7 (12.2)	13.3 (9.1)
Migraine subtypes
MA sufferers	90 (15.1 %)	68 (16.6 %)	22 (11.8 %)
MO sufferers	506 (84.9 %)	341 (83.4 %)	165 (88.2 %)
Frequency of migraine attacks
≥ 1 attack/month	354 (59.4 %)	271 (66.3 %)*	86 (45.9 %)
< 1 attack/month	242 (50.6 %)	138 (33.7 %)	101 (54.1 %)
Mean scores (SD) of HIT-6	61.4 (8.7)	63.1 (8.9)*	57.7 (8.5)
Family history of migraine	329 (55.2 %)	235 (57.5 %)	94 (50.3 %)

Table 1. Clinical Background of Migraineurs

Total (n =596)

Women (n = 409)

Men (n = 187)

MA: migraine with aura; MO: migraine without aura; HIT-6: headache impact test-6. *P < 0.01 between women and men.

Mean age (SD) years

44.6 (9.4)

44.3 (9.4)

45.2 (9.3)

Mean duration of migraine (SD) years

16.7 (11.4)

18.7 (12.2)

13.3 (9.1)

Migraine subtypes

MA sufferers

90 (15.1 %)

68 (16.6 %)

22 (11.8 %)

MO sufferers

506 (84.9 %)

341 (83.4 %)

165 (88.2 %)

Frequency of migraine attacks

≥ 1 attack/month

354 (59.4 %)

271 (66.3 %)*

86 (45.9 %)

< 1 attack/month

242 (50.6 %)

138 (33.7 %)

101 (54.1 %)

Mean scores (SD) of HIT-6

61.4 (8.7)

63.1 (8.9)*

57.7 (8.5)

Family history of migraine

329 (55.2 %)

235 (57.5 %)

94 (50.3 %)

**Table 2.** CVD Risk Factors of Migraineurs and Controls
	Migraineurs (n = 596)	Controls (n = 599)
P < 0.01 and *P < 0.001 between female migraineurs and female controls. ^†P < 0.01 between male migraineurs and male controls. CVD: cardiovascular disease; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolicblood pressure; FBS: fasting blood sugar; HbA_1c: hemoglobin A_1C; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglyceride; CRP: C-reactive protein; FH: family history.
Mean age (SD) years	44.3 (9.4)	45.3 (9.4)	44.2 (9.3)	45.7 (8.1)
BMI kg/m²	21.5 (3.2)	24.0 (3.7)	21.2 (2.6)	23.7 (3.1)
West/height	48.9 (5.5)	49.2 (5.5))	49.2 (5.5)	48.9 (4.7)
Smoking index	56.2 (118.7)	287.2 (334.0)	59.3 (140.6)	282.2 (277.0)
SBP mmHg	109.4 (14.5)*	119.7 (13.9)^†	106.8 (13.6)	116.2 (13.3)
DBP mm Hg	68.6 (9.5)*	73.7 (9.5)^†	66.0 (8.8)	70.7 (9.5)
FBS mg/dL	93.5 (8.8)	99.9 (15.4)	92.6 (11.7)	99.6 (12.5)
HbA_1c %	5.3 (0.9)	5.3 (0,9)	5.3 (1.0)	5.4 (1.0)
TC mg/dL	210.3 (34.2)*	209.3 (32.4)^†	201.5 (35.2)	202.0 (33.0)
HDL-C mg/dL	67.4 (14.2)**	53.5 (13.3)^†	71.8(14.8)	56.5 (13.6)
LDL-C mg/dL	118.9 (30.1)*	129.8 (29.0)^†	109.6 (30.6)	121.5 (30.5)
TG mg/dL	71.7 (40.7)	134.5 (91.6)^†	67.3 (33.4)	112.0 (77.8)
CRP mg/dL	0.09 (0.24)	0.13 (0.21)	0.09 (0.32)	0.23 (0.53)
FH of CVD or stroke	89 (21.8 %)**	38 (20.3 %)^†	51 (12.7 %)	21 (10.7 %)

Table 2. CVD Risk Factors of Migraineurs and Controls

Migraineurs (n = 596)

Controls (n = 599)

Women (n = 409)

Men (n = 187)

Women (n = 402)

Men (n = 197)

*P < 0.01 and **P < 0.001 between female migraineurs and female controls. ^†P < 0.01 between male migraineurs and male controls. CVD: cardiovascular disease; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolicblood pressure; FBS: fasting blood sugar; HbA_1c: hemoglobin A_1C; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglyceride; CRP: C-reactive protein; FH: family history.

Mean age (SD) years

44.3 (9.4)

45.3 (9.4)

44.2 (9.3)

45.7 (8.1)

BMI kg/m²

21.5 (3.2)

24.0 (3.7)

21.2 (2.6)

23.7 (3.1)

West/height

48.9 (5.5)

49.2 (5.5))

49.2 (5.5)

48.9 (4.7)

Smoking index

56.2 (118.7)

287.2 (334.0)

59.3 (140.6)

282.2 (277.0)

SBP mmHg

109.4 (14.5)*

119.7 (13.9)^†

106.8 (13.6)

116.2 (13.3)

DBP mm Hg

68.6 (9.5)*

73.7 (9.5)^†

66.0 (8.8)

70.7 (9.5)

FBS mg/dL

93.5 (8.8)

99.9 (15.4)

92.6 (11.7)

99.6 (12.5)

HbA_1c %

5.3 (0.9)

5.3 (0,9)

5.3 (1.0)

5.4 (1.0)

TC mg/dL

210.3 (34.2)*

209.3 (32.4)^†

201.5 (35.2)

202.0 (33.0)

HDL-C mg/dL

67.4 (14.2)**

53.5 (13.3)^†

71.8(14.8)

56.5 (13.6)

LDL-C mg/dL

118.9 (30.1)*

129.8 (29.0)^†

109.6 (30.6)

121.5 (30.5)

TG mg/dL

71.7 (40.7)

134.5 (91.6)^†

67.3 (33.4)

112.0 (77.8)

CRP mg/dL

0.09 (0.24)

0.13 (0.21)

0.09 (0.32)

0.23 (0.53)

FH of CVD or stroke

89 (21.8 %)**

38 (20.3 %)^†

51 (12.7 %)

21 (10.7 %)

**Table 3.** CVD Risk Factors of MA, MO and Control Subjects
	MA (n = 90)	MO (n = 506)	Controls (n = 599)
P < 0.05 and *P < 0.01 between female migraineurs and female controls. ^†P < 0.05 and ^††P < 0.01 between male migraineurs and male controls. CVD: cardiovascular disease; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; FBS: fasting blood sugar; HbA_1c: hemoglobin A_1C; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglyceride; CRP: C-reactive protein; FH: family history.
Mean age (SD) years	44.3 (9.7)	44.8 (9.2)	44.7 (9.0)
Women/men	68/22	341/165	402/197
BMI kg/m²	22.5 (3.5)	23.0 (4.1)	22.4 (3.1)
West/height	48.9 (5.6)	49.7 (5.6)	48.6 (4.7)
Smoking index	56.2 (118.7)	57.0 (121.6)	59.3 (140.6)
SBP mm Hg	115.4 (15.5)*	114.7 (14.9)^†	111.2 (14.2)
DBP mm Hg	70.2 (9.1)*	70.3 (9.7)^†	68.2 (9.5)
FBS mg/dL	98.5 (10.8)	98.9 (15.3)	96.0 (12.6)
HbA_1c %	5.4 (1.0)	5.3 (0.9)	5.3 (1.0)
TC mg/dL	210.5 (35.1)**	209.3 (38.4)^††	201.5 (34.2)
HDL-C mg/dL	62.9 (14.2)	63.2 (15.6)	64.4 (16.2)
LDL-C mg/dL	125.9 (34.1)**	123.8 (30.1)^††	115.4 (31.1)
TG mg/dL	91.7 (70.7)	88.5 (81.6)	88.8 (63.2)
CRP mg/dL	0.11 (0.30)	0.10 (0.41)	0.11 (0.33)
FH of CVD or stroke	25 (27.8%)**	102 (20.2%)^††	72 (12. 0%)

Table 3. CVD Risk Factors of MA, MO and Control Subjects

MA (n = 90)

MO (n = 506)

Controls (n = 599)

*P < 0.05 and **P < 0.01 between female migraineurs and female controls. ^†P < 0.05 and ^††P < 0.01 between male migraineurs and male controls. CVD: cardiovascular disease; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; FBS: fasting blood sugar; HbA_1c: hemoglobin A_1C; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglyceride; CRP: C-reactive protein; FH: family history.

Mean age (SD) years

44.3 (9.7)

44.8 (9.2)

44.7 (9.0)

Women/men

68/22

341/165

402/197

BMI kg/m²

22.5 (3.5)

23.0 (4.1)

22.4 (3.1)

West/height

48.9 (5.6)

49.7 (5.6)

48.6 (4.7)

Smoking index

56.2 (118.7)

57.0 (121.6)

59.3 (140.6)

SBP mm Hg

115.4 (15.5)*

114.7 (14.9)^†

111.2 (14.2)

DBP mm Hg

70.2 (9.1)*

70.3 (9.7)^†

68.2 (9.5)

FBS mg/dL

98.5 (10.8)

98.9 (15.3)

96.0 (12.6)

HbA_1c %

5.4 (1.0)

5.3 (0.9)

5.3 (1.0)

TC mg/dL

210.5 (35.1)**

209.3 (38.4)^††

201.5 (34.2)

HDL-C mg/dL

62.9 (14.2)

63.2 (15.6)

64.4 (16.2)

LDL-C mg/dL

125.9 (34.1)**

123.8 (30.1)^††

115.4 (31.1)

TG mg/dL

91.7 (70.7)

88.5 (81.6)

88.8 (63.2)

CRP mg/dL

0.11 (0.30)

0.10 (0.41)

0.11 (0.33)

FH of CVD or stroke

25 (27.8%)**

102 (20.2%)^††

72 (12. 0%)