Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc |
Journal website https://www.neurores.org |
Original Article
Volume 14, Number 2, December 2024, pages 74-85
Demographics and Clinical Correlates of Blood Pressure Among Ugandans at Risk for Stroke
Figures
Tables
Variables | N (%) | Mean (SD), range |
---|---|---|
aIncludes self-employed work at home or farming. bObesity defined as BMI > 30. cESC-ESH grade 1: SBP 140 - 159 mm Hg and/or DBP 90 - 99 mm Hg; grade 2: SBP 160 - 179 mm Hg and/or DBP 100 - 109 mm Hg; grade 3: SBP ≥ 180 mm Hg and/or DBP ≥ 110 mm Hg. dHarmful drinking behaviors based on AUDIT score defined as total score > 8. eCurrent smoke based on baseline assessment using the Global Adult Tobacco Survey (GATS). SD: standard deviation; HTN: hypertension; BMI: body mass index; AUDIT: Alcohol Use Disorders Identification Test; TEAM: TargetEd manAgeMent Intervention; SBP: systolic blood pressure; DBP: diastolic blood pressure; HbA1c: glycosylated hemoglobin; HDL: high-density lipoprotein; LDL: low-density lipoprotein; TIA: transient ischemic attack; ESC-ESH: the European Society of Cardiology and the European Society of Hypertension. | ||
Age (years) | 55.4 (12.0), 20 - 90 | |
Gender | ||
Male | 79 (32.0) | |
Female | 168 (68.0) | |
Educational level | ||
None | 18 (7.3) | |
Primary | 118 (47.8) | |
Secondary | 87 (35.2) | |
Tertiary | 24 (9.7) | |
Marital status | ||
Single | 15 (6.1) | |
Married | 132 (53.4) | |
Separated/divorced/widowed | 100 (40.5) | |
Currently employed/workinga | 162 (65.6) | |
Residency status | ||
Rural | 53 (21.5) | |
Suburban | 83 (33.6) | |
Urban | 111 (44.9) | |
Family stroke history | 50 (20.2) | |
Stroke risk factors at screening | ||
SBP ≥ 140 mm Hg | 247 (100) | |
Diabetes | 72 (29.1) | |
Hyperlipidemia | 199 (80.6) | |
Obesityb | 98 (39.7) | |
Current smoker | 3 (1.2) | |
Sedentary lifestyle | 58 (23.5) | |
Problem alcohol use | 26 (10.5) | |
Personal history of stroke or TIA | 49 (19.8) | |
Total number of stroke risk factors (including HTN) at screening | 3.0 (0.9), 2 - 6 | |
SBP at screen | 158.1 (14.9), 140 - 216 | |
DBP at screen | 95.4 (11.4), 71.5 - 132 | |
SBP at baseline | 143.0 (19.8), 94.5 - 206 | |
DBP at baseline | 89.3 (14.0), 61 - 136 | |
ESC-ESH 2018 Guideline HTNc at baseline | ||
< Grade 1 (SBP < 140 and DBP < 90) | 93 (37.7) | |
Grade 1 | 83 (33.6) | |
Grade 2 | 47 (19.0) | |
Grade 3 | 24 (9.7) | |
Serum cholesterol | 4.5 (1.1), 1.7 - 7.1 | |
Proportion with elevated value | 61 (24.7) | |
Serum HDL | 1.6 (2.8), 0.3 - 4.4 | |
Proportion with abnormal (low) value | ||
Men (n = 79) | 25 (31.6) | |
Women (n = 166) | 90 (54.2) | |
Serum LDL | 3.0 (1.3), 0.4 - 8.3 | |
Proportion with elevated value | 82 (33.2) | |
Serum triglycerides | 1.6 (1.0), 0.3 - 7.7 | |
Proportion with elevated value | 84 (34.0) | |
HbA1c (total sample) | 6.1 (1.9), 2.0 - 15.0 | |
HBA1c (those with diabetes) | 8.4 (1.8), 6.5 - 15.0 | |
BMI | 28.7 (5.8), 16.8 - 45.5 | |
Proportion with obesity | 98 (39.7) | |
AUDIT total score | 1.0 (3.5), 0 - 30 | |
Proportion with harmful drinking behaviord | 8 (4.9) | |
Current smokere, N (%) | 4 (1.6) | |
Receiving medication treatment for stroke/cardiovascular risk reduction | ||
No | 5 (2.0) | |
Yes (at least 1 drug) | 242 (98.0) | |
Number of medication treatments, mean (SD) | 3.0 (1.2), 0 - 6 | |
Sample prescribed a single medication | 16 (6.6) | |
Sample prescribed two treatments | 67 (27.7) | |
Sample prescribed three or more treatments | 159 (65.7) |
Variables | ESC-ESH HTN gradesa | Significant difference between groups | |||
---|---|---|---|---|---|
(A) < Grade 1 (n = 93, 37.7%), mean (SD) or N (%) | (B) Grade 1 (n = 83, 33.6%), mean (SD) or N (%) | (C) Grade 2 (n = 47, 19.0%), mean (SD) or N (%) | (D) Grade 3 (n = 24, 9.7%), mean (SD) or N (%) | ||
aESC-ESH grade 1: SBP 140 - 159 mm Hg and/or DBP 90 - 99 mm Hg; grade 2: SBP 160 - 179 mm Hg and/or DBP 100 - 109 mm Hg; grade 3: SBP ≥ 180 mm Hg and/or DBP ≥ 110 mm Hg. bIncludes self-employed work at home or farming. cCurrent smoker based on baseline assessment using the Global Adult Tobacco Survey (GATS). *P < 0.05; **P < 0.01; ***P < 0.001. SD: standard deviation; HTN: hypertension; BMI: body mass index; AUDIT: Alcohol Use Disorders Identification Test; TEAM: TargetEd manAgeMent Intervention; SBP: systolic blood pressure; DBP: diastolic blood pressure; HbA1c: glycosylated hemoglobin; HDL: high-density lipoprotein; LDL: low-density lipoprotein; ESC-ESH: the European Society of Cardiology and the European Society of Hypertension. | |||||
Age (years), mean (SD) | 56.3 (12.0) | 55.8 (11.9) | 56.1 (13.5) | 49.6 (7.8) | ns; A, B > D |
Gender, n (%) | |||||
Male | 27 (29.0) | 27 (32.5) | 17 (36.2) | 8 (33.3) | |
Female | 66 (71.0) | 56 (67.5) | 30 (63.8) | 16 (66.7) | ns |
Educational level, n (%) | |||||
None | 5 (5.4) | 9 (10.8) | 2 (4.3) | 2 (8.3) | |
Primary | 42 (45.2) | 37 (44.6) | 27 (57.4) | 12 (50.0) | |
Secondary | 37 (39.8) | 27 (32.5) | 13 (27.7) | 10 (41.7) | |
Tertiary | 9 (9.7) | 10 (12.0) | 5 (10.6) | 0 (0.0) | ns |
Marital status, n (%) | |||||
Single | 10 (10.8) | 3 (3.6) | 2 (4.3) | 0 (0.0) | |
Married | 43 (46.2) | 43 (51.8) | 29 (61.7) | 17 (70.8) | |
Separated/divorced/widow | 40 (43.0) | 37 (44.6) | 16 (34.0) | 7 (29.2) | ns |
Currently employed/workingb | 56 (60.2) | 58 (69.9) | 30 (63.8) | 18 (75.0) | ns |
Residency status, n (%) | |||||
Rural | 14 (15.1) | 19 (22.9) | 15 (31.9) | 5 (20.8) | |
Suburban | 37 (39.8) | 23 (27.7) | 12 (25.5) | 11 (45.8) | |
Urban | 42 (45.2) | 41 (49.4) | 20 (42.6) | 8 (33.2) | ns |
Stroke family history, n (%) | 19 (20.4) | 16 (19.3) | 12 (25.5) | 3 (12.5) | ns |
Stroke risk factors at screening, n (%) | |||||
Diabetes | 16 (17.2) | 30 (36.1) | 19 (40.4) | 7 (29.2) | **; C, B > A |
Hyperlipidemia | 77 (82.8) | 68 (81.9) | 36 (76.6) | 18 (75.0) | ns |
Obesity | 39 (41.9) | 34 (41.0) | 18 (38.3) | 7 (29.2) | ns |
Current smoker | 2 (2.2) | 0 (0.0) | 0 (0.0) | 1 (4.2) | ns |
Sedentary lifestyle | 27 (29.0) | 12 (14.5) | 10 (21.3) | 9 (37.5) | * |
Problem alcohol use | 10 (10.8) | 6 (7.2) | 7 (14.9) | 3 (12.5) | ns |
Personal stroke history | 29 (31.2) | 12 (14.5 | 5 (10.6) | 3 (12.5) | **; A > C |
Total number of risk factors at screening, mean (SD) | 3.0 (1.0) | 3.0 (0.8) | 2.9 (1.0) | 3.1 (1.1) | ns |
SBP at baseline, mean (SD) | 124.3 (10.4) | 145.4 (6.8) | 158.8 (10.9) | 176.0 (16.6) | ***; D > C > B > A |
DBP at baseline, mean (SD) | 77.8 (7.4) | 88.6 (6.9) | 99.9 (7.7) | 115.9 (8.9) | ***; D > C > B > A |
Serum cholesterol, mean (SD) | 4.8 (1.1) | 4.4 (1.2) | 4.4 (1.0) | 4.4 (1.2) | ns |
Serum HDL, mean (SD) | 1.3 (0.6) | 1.3 (0.6) | 1.4 (0.6) | 1.3 (0.5) | ns |
Serum LDL, mean (SD) | 3.1 (1.0) | 3.2 (1.7) | 2.6 (1.0) | 3.0 (1.6) | *; A > C |
Serum triglycerides | 1.6 (1.0) | 1.7 (0.8) | 1.8 (1.3) | 1.6 (1.0) | ns |
HbA1c, mean (SD) | 5.8 (1.7) | 6.2 (2.0) | 6.5 (1.9) | 6.2 (2.4) | ns |
BMI, mean (SD) | 29.4 (6.1) | 28.3 (5.5) | 28.8 (6.0) | 27.3 (5.0) | ns |
AUDIT, mean (SD) | 0.7 (1.9) | 0.8 (2.6) | 1.0 (3.4) | 3.0 (8.2) | ns |
Current smokerc, n (%) | 1 (1.1) | 1 (1.2) | 0 (0.0) | 2 (8.3) | * |
Receiving medication treatment for cardiovascular risk reduction, n (%) (at least 1 drug) | 92 (98.9) | 81 (97.6) | 47 (100.0) | 22 (91.7) | ns |
Number of medication treatments, mean (SD) | 3.0 (1.1) | 2.9 (1.2) | 3.0 (1.2) | 3.4 (1.5) | ns |
Number of individuals on a single treatment, n (%) | 5 (5.4) | 7 (8.6) | 4 (8.5) | 0 (0.0) | ns |
Number of individuals on two treatments, n (%) | 27 (29.3) | 21 (25.9) | 15 (31.9) | 4 (18.2) | ns |
Number of individuals on three or more treatments, n (%) | 60 (65.2) | 53 (65.4) | 28 (59.6) | 18 (81.8) | ns |
Variables | SBP | DBP | ESC-ESH HTN severity gradea |
---|---|---|---|
aESC-ESH grade 1: SBP 140 - 159 mm Hg and/or DBP 90 - 99 mm Hg; grade 2: SBP 160 - 179 mm Hg and/or DBP 100 - 109 mm Hg; grade 3: SBP ≥ 180 mm Hg and/or DBP ≥ 110 mm Hg. bIncludes self-employed work at home or farming. cCurrent smoker based on baseline assessment using the Global Adult Tobacco Survey (GATS). *P < 0.05, **P < 0.01, ***P < 0.001. SD: standard deviation; HTN: hypertension; BMI: body mass index; AUDIT: alcohol use disorders identification test; SBP: systolic blood pressure; DBP: diastolic blood pressure; HbA1c: glycosylated hemoglobin; HDL: high-density lipoprotein; LDL: low-density lipoprotein; ESC-ESH: the European Society of Cardiology and the European Society of Hypertension; TEAM: TargetEd manAgeMent Intervention. | |||
Age (years) | -0.01 | -0.24*** | -0.11 |
Female | -0.04 | 0.03 | -0.05 |
Educational level | -0.08 | -0.06 | -0.08 |
Married | 0.13* | 0.17** | 0.16* |
Currently employed/workingb | 0.07 | 0.14* | 0.08 |
Residency status (n = 129) | |||
Rural | 0.16 | 0.13 | 0.16 |
Stroke history | |||
Family (yes) | 0.02 | 0.02 | -0.01 |
Stroke risk factors at baseline | |||
Diabetes | 0.19** | 0.10 | 0.15* |
Hyperlipidemia | -0.04 | -0.05 | -0.07 |
Obesity | -0.03 | -0.06 | -0.07 |
Current smoker | -0.01 | -0.02 | -0.00 |
Sedentary life style | -0.04 | -0.01 | 0.01 |
Personal stroke history | -0.19** | -0.18** | -0.19** |
Total number of risk factors at screening (including HTN) | -0.00 | 0.06 | 0.02 |
SBP | 1.00*** | 0.76*** | 0.85*** |
DBP | 0.76*** | 1.00*** | 0.84*** |
ESC-ESH 2018 Guideline HTN European grade | 0.85*** | 0.84*** | 1.00*** |
Serum cholesterol | -0.05 | -0.11 | -0.12 |
Serum HDL | 0.02 | -0.04 | 0.00 |
Serum LDL | -0.09 | -0.07 | -0.09 |
Serum triglycerides | 0.09 | -0.05 | 0.04 |
HbA1c | 0.18** | 0.05 | 0.10 |
BMI | -0.07 | -0.07 | -0.09 |
AUDIT total score | 0.14* | 0.14* | 0.15* |
Current smokerc, N (%) | 0.07 | 0.13 | 0.10 |
Receiving medication treatment for cardiovascular risk | -0.03 | -0.10 | -0.09 |
Number of medication treatments | 0.13* | 0.07 | 0.07 |