Evaluation of the Effects of Aspirin and Warfarin Use on the Volume of Intracranial Non-Traumatic Hemorrhage and Mortality Rate

Abstract

Background: To evaluate the effects of aspirin and warfarin use on the volume of intracranial hemorrhage and mortality rates.

Methods: The patients using aspirin and warfarin with intracranial non-traumatic hemorrhage were enrolled the study. Control group included the patients with intracerebral non-traumatic hemorrhage but not using any oral antiaggregant or anticoagulant agent. This is an open, prospective and controlled study. In the statistical analysis, chi-square test, T test, non-parametrical Mann Whitney U test, and Pearson’s coefficient of correlation were used.

Results: Total 104 hospitalized patients with intracranial hemorrhage were enrolled to the study, 47 (45%) of them were using aspirin or warfarin and 57 (55%) were not using. Mean age was 66.5 (± 12.04), 38 patients (36.5%) were using aspirin and 9 (8.65%) were using warfarin. At the end of eight months 10 (26.3%) patients using aspirin, 5 patients (55.6%) using warfarin, and 16 (26%) patients in the control group died. There was a statistically important difference between patients using aspirin/warfarin and control group (P < 0.05) in the hemorrhage volume. Aspirin or warfarin use did not have any effect on mortality rates (P > 0.05). Hemorrhages with ventricular extension did not have any significant effect on hemorrhage volume or mortality rate.

Conclusion: Aspirin and warfarin use increases hemorrhage volume in a statistically significant ratio, however no significant effect on mortality rate.




J Neurol Res. 2012;2(3):99-103
doi: https://doi.org/10.4021/jnr100w