Comparison the Serum Level of Prolactin Among Patients With Chronic and Episodic Migraine

Abstract

Background: Increased serum prolactin level is suggested as one of factors for migraine to being chronic. The Aim of this study is comparison the serum level of prolactin among patients with chronic and episodic migraine.

Methods: This cross-sectional study was performed from 2011 July till 2012 November among 114 female migrainous. The subjects who involved by menstrual irregularity, anxiety, depression, hypo or hypothyroidism, anemia, polycythemia, epilepsy, and pregnant, lactating, prepuberty and postmenopause patients and hormonal preparations users didn’t entered study. The patients must avoid from any temporary affecting factors on prolactin serum level in the last 12 hours. Fasting blood was taken in the period of follicular phase and the serum level of prolactin was determined by ELISA method and compared between 2 groups. The data analysis was performed by T-test, Mann Weithney U and Qui² tests in SPSS 19 software.

Results: A total of 57 patients with chronic migraine and 57 patients with episodic migraine with mean age of 33.0 ± 8.8 and 32.7 ± 8.7 years old respectively (P = 0.712) participated in this study. The mean serum level of prolactin was 20.92 ± 12.14 ng/dL (95% CI: 17.69 - 24.14) and 16.36 ± 9.34 ng/dL (95% CI: 13.88 - 18.84) respectively (P = 0.036). Also with omitting the age effect the difference was significant (P = 0.022). The prevalence of hyperprolactinemia in chronic and episodic migraine was 28.1% and 12.3% (P = 0.036) (OR = 2.8, 95% CI: 7.42 - 1.04).

Conclusion: The prolactin serum level and the prevalence of hyperprolactinemia in chronic migrainous was higher than episodic ones.




J Neurol Res. 2013;3(2):68-72
doi: https://doi.org/10.4021/jnr189w