Rare Combination of Adverse Effects Associated With Lamotrigine Treatment

Abstract

Lamotrigine (LTG) is an antiepileptic drug which is widely used in treatment of epilepsy. It is effective as an adjunctive treatment of refractory partial seizures and idiopathic generalized epilepsy in adults and children. However, patients are subject to some adverse effects with ongoing medication of LTG. Rare events associated with LTG medication such as hematological abnormalities and skin lesions have utmost clinical importance and often cause drug withdrawal. We present a case of a 23-year-old male who had leukopenia, thrombocytopenia and rash associated with LTG treatment. Clinician must be aware of serious side effects of LTG especially at the beginning of the treatment. Serious adverse effects such as leukopenia, thrombocytopenia and rash should be considered along with the other insignificant complaints such as nausea, dizziness and malaise.




J Neurol Res. 2018;8(1-2):10-12
doi: https://doi.org/10.14740/jnr442w