Malignant Peripheral Nerve Sheath Tumor of the Mandible: A Case Report and Review of Literature

Abstract

Malignant peripheral nerve sheath tumor of the mandible is an uncommon tumor. We describe a rare case of MPNST involving the mandible with chondrosarcomatous differentiation. It is important to recognize the sarcomatous origin in such tumors and distinguish it from the malignant divergent elements since the management strategy varies considerably. The difficulties faced in MPNST involving the head and neck region is to obtain adequate negative margins with surgery, since the most important prognostic factor for survival is positive margins. The treatment approach is similar to that of other soft tissue sarcomas. Adjuvant radiotherapy plays an important role in decreasing local recurrence.




J Neurol Res. 2011;1(5):219-222
doi: https://doi.org/10.4021/jnr74e