Serum Progesterone as an Admission Prognostic Marker in Male Traumatic Brain Injury Patients

Abstract

Background: In this prospective study, we analyzed data in men with moderate traumatic brain injury, to find whether higher levels of serum progesterone at admission are associated with better prognosis.

Methods: One hundred male patients of traumatic brain injury, with a postresuscitation Glasgow Coma Scale score between 4 to 12 were enrolled and serum for progesterone collected at admission. Outcome was assessed 30 days postinjury according to Glasgow Outcome Scale (GOS) and Functional Independence Measure (FIM) score.

Results: The mean progesterone level in the group with GOS ≤ 3 was 0.89 ± 033 ng/mL as compared to 1.03 ± 0.18 ng/mL in those with GOS > 3  ( P value 0.1409) and 0.9 ± 0.45 ng/mL in the group with FIM ≤ 4 compared to 1.27 ± 0.32  ng/mL in the group with FIM > 4 (P value 0.0474).

Conclusion: We concluded that lower progesterone levels are associated with poorer outcome measures in male traumatic brain injury patients.




J Neurol Res. 2012;2(2):44-47
doi: https://doi.org/10.4021/jnr101w