Serum Progesterone as an Admission Prognostic Marker in Male Traumatic Brain Injury Patients

Abstract

Background: In this prospective study, we analyzed data in men with moderate traumatic brain injury, to findÂwhether higher levels ofÂserum progesterone at admission are associated with better prognosis.

Methods: One hundred maleÂpatients of traumatic brain injury, with a postresuscitation Glasgow Coma Scale score between 4 to 12 were enrolled and serum forÂprogesterone collected at admission. Outcome was assessed 30 days postinjury according toÂGlasgow Outcome Scale (GOS) andÂFunctional Independence Measure (FIM) score.

Results: The mean progesterone level in the group with GOS ≤ 3 was 0.89 ± 033 ng/mL as compared to 1.03 ± 0.18 ng/mL in those with GOS > 3 ( P value 0.1409) and 0.9 ± 0.45 ng/mL in the group with FIM ≤ 4 compared to 1.27 ± 0.32 Âng/mLÂin the group with FIM > 4Â(P value 0.0474).

Conclusion: We concluded that lower progesterone levels areÂassociated with poorer outcome measures in male traumatic brain injury patients.




J Neurol Res. 2012;2(2):44-47
doi: https://doi.org/10.4021/jnr101w